Form 424B2 BARCLAYS BANK PLC

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May 2021 Registration Statement No. 333-232144 Pricing Supplement dated May , 2021 Filed pursuant to Rule 424(b)(2)

Structured
Investments

Opportunities in U.S. Equities

Contingent Income Auto-Callable Securities due
May 17, 2024

Based
on the Performance of the Common Stock of Tesla, Inc.

Principal
at Risk Securities

Unlike conventional debt securities, the securities do not guarantee
the payment of interest or any return of principal at maturity. Instead, the securities offer the opportunity for investors to receive
a contingent quarterly payment equal to at least 4.4625% of the stated principal amount (the actual contingent quarterly payment will
be determined on the pricing date) with respect to each quarterly determination date on which the closing price of the underlier is greater
than or equal to 50% of the initial underlier value, which we refer to as the downside threshold level. If the closing price of the underlier
is greater than or equal to the initial underlier value on any determination date (other than the final determination date), the securities
will be automatically redeemed for an amount per security equal to the stated principal amount plus the contingent quarterly payment
otherwise due. However, if on any determination date the closing price of the underlier is less than the initial underlier value, the
securities will not be redeemed and if that closing price is less than the downside threshold level, investors will not receive any contingent
quarterly payment for the related quarterly period. If the securities are not redeemed prior to maturity and the final underlier value
is greater than or equal to the downside threshold level, the payment at maturity due on the securities will be equal to the stated principal
amount plus the contingent quarterly payment otherwise due. However, if the securities are not redeemed prior to maturity and
the final underlier value is less than the downside threshold level, at maturity investors will lose 1% of the stated principal amount
for every 1% that the final underlier value is less than the initial underlier value. Under these circumstances, the amount investors
receive will be less than 50% of the stated principal amount and could be zero. The securities are for investors who are willing and
able to risk their principal and forgo guaranteed interest payments, in exchange for the opportunity to receive contingent quarterly
payments at a potentially above-market rate, subject to automatic early redemption. Investors will not participate in any appreciation
of the underlier even though investors will be exposed to the depreciation in the value of the underlier if the securities have not been
redeemed prior to maturity and the final underlier value is less than the downside threshold level. Investors may lose their entire
initial investment in the securities. The securities are unsecured and unsubordinated debt obligations of Barclays Bank PLC. Any payment
on the securities, including any repayment of principal, is subject to the creditworthiness of Barclays Bank PLC and is not guaranteed
by any third party. If Barclays Bank PLC were to default on its payment obligations or become subject to the exercise of any U.K. Bail-in
Power (as described on page 5 of this document) by the relevant U.K. resolution authority, you might not receive any…